Ketoconazole (systemic) vs Zolpidem

Interacting Drugs
Ketoconazole (systemic)
vs
Zolpidem
Security Level
Moderate, Consider therapy modification
Mechanism
Zolpidem: Antifungal Agents (Azole Derivatives, Systemic) may increase the serum concentration of Zolpidem.
Management
Consider using a lower starting dose of zolpidem in patients receiving systemic azole antifungals. Monitor patients closely for increased magnitude and/or duration of zolpidem effects when using this combination.

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