Ketoconazole (systemic) vs Ticagrelor

Interacting Drugs
Ketoconazole (systemic)
vs
Ticagrelor
Security Level
Major, Avoid combination
Mechanism
Ticagrelor: CYP3A4 Inhibitors (Strong) may decrease serum concentrations of the active metabolite(s) of Ticagrelor. CYP3A4 Inhibitors (Strong) may increase the serum concentration of Ticagrelor.
Management
Avoid combination

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