Ketoconazole (systemic) vs Tamoxifen

Interacting Drugs
Ketoconazole (systemic)
vs
Tamoxifen
Security Level
Moderate, Consider therapy modification
Mechanism
Tamoxifen: CYP2D6 Inhibitors (Moderate) may decrease the metabolism of Tamoxifen. Specifically, CYP2D6 inhibitors may decrease the formation of highly potent active metabolites.
Management
Consider alternatives with less of an inhibitory effect on CYP2D6 activity when possible.

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