Ketoconazole (systemic) vs Tadalafil

Interacting Drugs
Ketoconazole (systemic)
vs
Tadalafil
Security Level
Moderate, Consider therapy modification
Mechanism
Tadalafil: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Tadalafil.
Management
Erectile dysfunction: tadalafil max = 2.5 mg/day (daily use) or 10 mg/72 hrs (as needed use) (adult doses). Avoid use of tadalafil with a strong CYP3A4 inhibitor for treatment of pulmonary arterial hypertension.

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