Ketoconazole (systemic) vs Tacrolimus

Interacting Drugs
Ketoconazole (systemic)
vs
Tacrolimus
Security Level
Moderate, Consider therapy modification
Mechanism
Tacrolimus: Ketoconazole (Systemic) may increase the serum concentration of Tacrolimus.
Management
Tacrolimus dose adjustment may be required when taken with ketoconazole due to elevated plasma concentrations of tacrolimus. Monitor tacrolimus concentrations and clinical response closely.

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