Interacting Drugs |
Ketoconazole (systemic) vs Sirolimus |
Security Level |
 |
Mechanism |
Sirolimus: Ketoconazole (Systemic) may increase the serum concentration of Sirolimus. |
Management |
Sirolimus dose adjustments will likely be needed when starting/stopping any azole antifungal. Clinical data suggest sirolimus (adult) dose reductions of 50-90% will be needed when starting an azole antifungal, but specific guidelines are lacking. |
Ketoconazole (systemic) vs Sirolimus
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Other Interactions of Ketoconazole (systemic)
Other Interactions of Sirolimus
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