Ketoconazole (systemic) vs Phenytoin

Interacting Drugs
Ketoconazole (systemic)
vs
Phenytoin
Security Level
Moderate, Consider therapy modification
Mechanism
Phenytoin: Antifungal Agents (Azole Derivatives, Systemic) may increase the serum concentration of Phenytoin. Phenytoin may decrease the serum concentration of Antifungal Agents (Azole Derivatives, Systemic).
Management
Consider therapy modification

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