Ketoconazole (systemic) vs Codeine

Interacting Drugs
Ketoconazole (systemic)
vs
Codeine
Security Level
Minor, Monitor Therapy
Mechanism
Codeine: CYP2D6 Inhibitors (Moderate) may diminish the therapeutic effect of Codeine. These CYP2D6 inhibitors may prevent the metabolic conversion of codeine to its active metabolite morphine.
Management
Monitor therapy

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