Ketoconazole (systemic) vs Almotriptan

Interacting Drugs
Ketoconazole (systemic)
vs
Almotriptan
Security Level
Moderate, Consider therapy modification
Mechanism
Almotriptan: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Almotriptan.
Management
Limit initial almotriptan adult dose to 6.25 mg and maximum adult dose to 12.5 mg/24-hrs when used with a strong CYP3A4 inhibitor. Avoid concurrent use in patients with impaired hepatic or renal function.

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