Isoniazid vs Fosphenytoin

Interacting Drugs
Isoniazid
vs
Fosphenytoin
Security Level
Moderate, Consider therapy modification
Mechanism
Fosphenytoin: Isoniazid may increase the serum concentration of Fosphenytoin.
Management
Consider alternatives. If concomitant therapy cannot be avoided, monitor for increased phenytoin concentrations/effects with isoniazid initiation/dose increase, or decreased concentrations/effects with isoniazid discontinuation/dose decrease.

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