Hydroxychloroquine vs Mefloquine

Interacting Drugs
Hydroxychloroquine
vs
Mefloquine
Security Level
Major, Avoid combination
Mechanism
Mefloquine: Aminoquinolines (Antimalarial) may enhance the adverse/toxic effect of Mefloquine. Specifically, the risk for QTc-prolongation and the risk for convulsions may be increased. Mefloquine may increase the serum concentration of Aminoquinolines (Antimalarial).
Management
Avoid concurrent use, and delay administration of mefloquine until at least 12 hours after the last dose of an aminoquinoline antimalarial when possible.

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Other Interactions of Hydroxychloroquine

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Other Interactions of Mefloquine

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