Hydroxychloroquine vs Dapsone

Interacting Drugs
Hydroxychloroquine
vs
Dapsone
Security Level
Moderate, Consider therapy modification
Mechanism
Dapsone: May enhance the adverse/toxic effect of Antimalarial Agents. More specifically, dapsone may increase the risk for hemolytic reactions. Antimalarial Agents may enhance the adverse/toxic effect of Dapsone. More specifically, antimalarial agents may increase the risk for hemolytic reactions.
Management
Closely monitor patients for signs/symptoms of hemolytic reactions with concomitant use of dapsone and antimalarial agents, particularly in patients deficient in glucose-6-phosphate dehydrogenase (G6PD), methemoglobin reductase, or with hemoglobin M.

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Other Interactions of Hydroxychloroquine

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Other Interactions of Dapsone

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