Fosphenytoin vs Valproic Acid

Interacting Drugs
Fosphenytoin
vs
Valproic Acid
Security Level
Minor, Monitor Therapy
Mechanism
Valproic Acid: Fosphenytoin may increase the metabolism of Valproic Acid. A hepatotoxic metabolite of valproic acid may result. Valproic Acid may decrease the serum concentration of Fosphenytoin. Continued therapy usually yields a normalization (or slight increase) of serum phenytoin concentrations. Free phenytoin concentrations, however, tend to remain relatively stable (possibly increased with continued therapy).
Management
Monitor therapy

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Other Interactions of Valproic Acid

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