Fosphenytoin vs Felbamate

Interacting Drugs
Fosphenytoin
vs
Felbamate
Security Level
Moderate, Consider therapy modification
Mechanism
Felbamate: Fosphenytoin may decrease the serum concentration of Felbamate. Felbamate may increase the serum concentration of Fosphenytoin.
Management
Decreased phenytoin dose will likely be needed when adding felbamate; some reports suggest an empiric 20% decrease in phenytoin dose. Additional reductions may be needed if felbamate dose is increased or as otherwise guided by monitoring.

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Other Interactions of Fosphenytoin

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Other Interactions of Felbamate

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