Interacting Drugs |
Fludarabine vs Imatinib |
Security Level |
 |
Mechanism |
Imatinib: May diminish the myelosuppressive effect of Fludarabine. Imatinib may decrease the serum concentration of Fludarabine. More specifically, imatinib may decrease the formation of fludarabine active metabolite F-ara-ATP |
Management |
Due to the risk for impaired fludarabine response, consider discontinuing imatinib therapy at least 5 days prior to initiating fludarabine conditioning therapy in CML patients undergoing HSCT. |
Fludarabine vs Imatinib
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Other Interactions of Fludarabine
Other Interactions of Imatinib
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