Esomeprazole vs Tacrolimus (Systemic)

Interacting Drugs
Esomeprazole
vs
Tacrolimus (Systemic)
Security Level
Moderate, Consider therapy modification
Mechanism
Tacrolimus (Systemic): Proton Pump Inhibitors may increase the serum concentration of Tacrolimus (Systemic).
Management
Tacrolimus dose adjustment may be required. Rabeprazole, pantoprazole, or selected H2-receptor antagonists (i.e., ranitidine or famotidine) may be less likely to interact. Genetic testing may predict patients at highest risk.

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