Efavirenz vs Voriconazole

Interacting Drugs
Efavirenz
vs
Voriconazole
Security Level
Moderate, Consider therapy modification
Mechanism
Voriconazole: Reverse Transcriptase Inhibitors (Non-Nucleoside) may decrease the serum concentration of Voriconazole. Voriconazole may increase the serum concentration of Reverse Transcriptase Inhibitors (Non-Nucleoside).
Management
Efavirenz and voriconazole should not be coadministered at standard doses. Concurrent use is acceptable if voriconazole is dosed at 400 mg every 12 hours and efavirenz is dosed at 300 mg daily (adult doses) throughout the course of therapy.

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Other Interactions of Voriconazole

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