Efavirenz vs Methadone

Interacting Drugs
Efavirenz
vs
Methadone
Security Level
Moderate, Consider therapy modification
Mechanism
Methadone: Reverse Transcriptase Inhibitors (Non-Nucleoside) may increase the metabolism of Methadone.
Management
Methadone dosage adjustments will likely be required with efavirenz and nevirapine, and may be necessary with rilpivirine as well.

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