Didanosine vs Stavudine

Interacting Drugs
Didanosine
vs
Stavudine
Security Level
Moderate, Consider therapy modification
Mechanism
Stavudine: May enhance the adverse/toxic effect of Didanosine. Lactic acidosis (possibly fatal) is of particular concern.
Management
Use extreme caution and monitor for lactic acidosis with concomitant stavudine and didanosine therapy. Avoid use of stavudine and didanosine (in combination or alone) with hydroxyurea due to increased risk of serious toxicity.

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