Didanosine vs Methadone

Interacting Drugs
Didanosine
vs
Methadone
Security Level
Moderate, Consider therapy modification
Mechanism
Methadone: May decrease the serum concentration of Didanosine.
Management
If use of methadone with didanosine is necessary, enteric coated didanosine is preferred. Avoid using didanosine powder for solution with methadone. Increased monitoring of clinical response to didanosine (including viral load) is necessary.

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