Darunavir vs Didanosine

Interacting Drugs
Darunavir
vs
Didanosine
Security Level
Moderate, Consider therapy modification
Mechanism
Didanosine: Darunavir may decrease the serum concentration of Didanosine. More specifically, this interaction is likely due to the effects of food (with which darunavir/ritonavir are taken) on didanosine, which is supposed to be given on an empty stomach.
Management
Didanosine should be administered 1 hour prior to or 2 hours after administration of darunavir/ritonavir (which must be taken with food).

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