Darunavir vs Calcium Channel Blockers (Nondihydropyridine)

Interacting Drugs
Darunavir
vs
Calcium Channel Blockers (Nondihydropyridine)
Security Level
Moderate, Consider therapy modification
Mechanism
Calcium Channel Blockers (Nondihydropyridine): Protease Inhibitors may decrease the metabolism of Calcium Channel Blockers (Nondihydropyridine). Increased serum concentrations of the calcium channel blocker may increase risk of AV nodal blockade.
Management
Avoid concurrent use when possible. If this combination is used, monitor for evidence of toxicity. The manufacturer of atazanavir recommends a 50% dose reduction for diltiazem be considered. Use of ritonavir with bepridil is contraindicated.

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Other Interactions of Darunavir

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Other Interactions of Calcium Channel Blockers (Nondihydropyridine)

We are Developing Our database, More results coming soon.