Darunavir vs Antifungal Agents (Azole Derivatives, Systemic)

Interacting Drugs
Darunavir
vs
Antifungal Agents (Azole Derivatives, Systemic)
Security Level
Moderate, Consider therapy modification
Mechanism
Antifungal Agents (Azole Derivatives, Systemic): May increase the serum concentration of Protease Inhibitors. Protease Inhibitors may increase the serum concentration of Antifungal Agents (Azole Derivatives, Systemic).
Management
Limit indinavir adult dose to 600 mg every 8 hours with itraconazole or ketoconazole. With ritonavir, limit ketoconazole adult dose to 200 mg/day. Limit fluconazole, itraconazole, and ketoconazole to 200 mg (adult dose) with tipranavir/ritonavir.

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Other Interactions of Darunavir

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Other Interactions of Antifungal Agents (Azole Derivatives, Systemic)

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