Dabigatran vs Verapamil

Interacting Drugs
Dabigatran
vs
Verapamil
Security Level
Moderate, Consider therapy modification
Mechanism
Verapamil: May increase serum concentrations of the active metabolite(s) of Dabigatran Etexilate.
Management
Canadian (but not U.S.) dabigatran prescribing information recommends limiting dose to 150 mg/day following orthopedic surgery (OS), dosing 2 hours prior to verapamil, and avoiding initiation of verapamil in patients receiving dabigatran following OS.

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