Cyproterone and ethinyl estradiol vs HMG-CoA Reductase Inhibitors

Interacting Drugs
Cyproterone and ethinyl estradiol
vs
HMG-CoA Reductase Inhibitors
Security Level
Moderate, Consider therapy modification
Mechanism
HMG-CoA Reductase Inhibitors: Cyproterone may increase the serum concentration of HMG-CoA Reductase Inhibitors.
Management
Avoid use of statins metabolized by CYP3A4 (eg, simvastatin) and consider avoiding fluvastatin as well in patients receiving high dose cyproterone (300 mg/day). Consider use of pravastatin, rosuvastatin, or pitavastatin if statin therapy is needed. Exceptions: Pitavastatin; Pravastatin; Rosuvastatin.

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Other Interactions of Cyproterone and ethinyl estradiol

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Other Interactions of HMG-CoA Reductase Inhibitors

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