Clonidine and chlorthalidone vs Amifostine

Interacting Drugs
Clonidine and chlorthalidone
vs
Amifostine
Security Level
Moderate, Consider therapy modification
Mechanism
Amifostine: Antihypertensives may enhance the hypotensive effect of Amifostine.
Management
When amifostine is used at chemotherapy doses, antihypertensive medications should be withheld for 24 hours prior to amifostine administration. If antihypertensive therapy can not be withheld, amifostine should not be administered.

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