Cinacalcet vs Tetrabenazine

Interacting Drugs
Cinacalcet
vs
Tetrabenazine
Security Level
Moderate, Consider therapy modification
Mechanism
Tetrabenazine: CYP2D6 Inhibitors (Strong) may increase the serum concentration of Tetrabenazine. Specifically, concentrations of the active alpha- and beta-dihydrotetrabenazine metabolites may be increased.
Management
Tetrabenazine adult dose should be reduced by 50% when starting a strong CYP2D6 inhibitor. Maximum tetrabenazine adult dose is 50 mg/day when used with a strong CYP2D6 inhibitor.

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