Ceftriaxone vs Ringer’s Injection (Lactated)

Interacting Drugs
Ceftriaxone
vs
Ringer's Injection (Lactated)
Security Level
Moderate, Consider therapy modification
Mechanism
Ringer's Injection (Lactated): May enhance the adverse/toxic effect of CefTRIAXone. Ceftriaxone binds to calcium in the Lactated Ringer's forming an insoluble precipitate.
Management
Use of ceftriaxone with calcium-containing solutions (including LR) within 48 hours of one another is contraindicated in neonates (28 days of age or younger). In older patients, flush lines with compatible fluid between administration.

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Other Interactions of Ringer's Injection (Lactated)

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