Carbidopa-levodopa-entacapone vs Pyridoxine

Interacting Drugs
Carbidopa-levodopa-entacapone
vs
Pyridoxine
Security Level
Moderate, Consider therapy modification
Mechanism
Pyridoxine: May diminish the therapeutic effect of Levodopa.
Management
The concomitant use of pyridoxine and levodopa (in the absence of a dopa decarboxylase inhibitor (DDI)) should be avoided. Use of a DDI (e.g., carbidopa) with levodopa will essentially eliminate the risk of this interaction.

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Other Interactions of Carbidopa-levodopa-entacapone

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Other Interactions of Pyridoxine

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