Butalbital, acetaminophen, and caffeine vs Felbamate

Interacting Drugs
Butalbital, acetaminophen, and caffeine
vs
Felbamate
Security Level
Minor, Monitor Therapy
Mechanism
Felbamate: May increase the serum concentration of Barbiturates. Barbiturates may decrease the serum concentration of Felbamate.
Management
Monitor for elevated barbiturate concentrations/toxicity if felbamate is initiated/dose increased, or reduced concentrations/effects if felbamate is discontinued/dose decreased. Refer to phenobarbital dosing guidelines for patients receiving that agent.

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