Atazanavir vs Proton Pump Inhibitors

Interacting Drugs
Atazanavir
vs
Proton Pump Inhibitors
Security Level
Moderate, Consider therapy modification
Mechanism
Proton Pump Inhibitors: May decrease the serum concentration of Atazanavir.
Management
Avoid concurrent PPI in HIV treatment-experienced patients. For treatment-naive patients, atazanavir/ritonavir dose should be given approximately 12 hours after the PPI, and the PPI should not exceed the equivalent of 20 mg omeprazole.

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Other Interactions of Proton Pump Inhibitors

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