Acetaminophen, dextromethorphan, and doxylamine vs Vitamin K Antagonists (eg, warfarin)

Interacting Drugs
Acetaminophen, dextromethorphan, and doxylamine
vs
Vitamin K Antagonists (eg, warfarin)
Security Level
Minor, Monitor Therapy
Mechanism
Vitamin K Antagonists (eg, warfarin): Acetaminophen may enhance the anticoagulant effect of Vitamin K Antagonists. Most likely with daily acetaminophen doses >1.3 g for >1 week.
Management
Monitor therapy

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