Acetaminophen, dextromethorphan, and doxylamine vs Selective Serotonin Reuptake Inhibitors

Interacting Drugs
Acetaminophen, dextromethorphan, and doxylamine
vs
Selective Serotonin Reuptake Inhibitors
Security Level
Moderate, Consider therapy modification
Mechanism
Selective Serotonin Reuptake Inhibitors: May enhance the serotonergic effect of Dextromethorphan. Selective Serotonin Reuptake Inhibitors may increase the serum concentration of Dextromethorphan.
Management
Avoid the concurrent use of dextromethorphan and SSRIs, particularly fluoxetine and paroxetine, when possible. The risk for this interaction may persist for several weeks following discontinuation of fluoxetine or paroxetine. Exceptions: FluvoxaMINE.

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