5-hydroxytryptophan vs Duloxetine

Interacting Drugs
Tryptophan
vs
Duloxetine
Security Level
Major, Avoid combination
Interaction Effect

duloxetine causes additive toxicity with 5-hydroxytryptophan

Mechanism

Coadministration of SNRIs and tryptophan (a serotonin precursor) may result in serotonin syndrome due to the additive serotonergic effects of these agents.

Management

Concurrent use should be avoided. Monitor the patient closely for signs and symptoms of serotonin syndrome (e.g. mental status changes, neuromuscular aberrations, autonomic instability and gastrointestinal symptoms) if the combination cannot be avoided. 


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Other Interactions of Tryptophan

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Other Interactions of Duloxetine

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