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Zinc Sulphate indications, dose, side effects & concise monograph

Zinc Sulphate

Therapeutic Class
Minerals
Indications

Oral
Zinc deficiency
Adult: 50 mg of elemental zinc tid.
Intravenous
Zinc deficiency
Adult: 6.5 mg elemental zinc (100 micromoles) daily. 
Ophthalmic
Minor eye irritation
Adult: In combination with a vasoconstrictor, 1-2 drops are instilled into the eye 2-4 times daily.

Incompatibility: Mixing sodium borate, glycerin and methylcellulose with zinc sulfate may cause preciptation.

Warnings / Precautions

Oral/IV: Monitor CBC and serum cholesterol to detect early signs of copper deficiency, especially if prolonged high dose use of zinc. Topical: Consult medical advice if relief not seen within 3 days.

Adverse Reactions

Abdominal pain, dyspepsia, nausea, vomiting, diarrhoea, gastric irritation, gastritis. Prolonged use may cause copper deficiency (e.g. sideroblastic anaemia, neutropenia)

Drug Interactions

Reduced absorption of both zinc and oral iron supplements, penicillamine and tetracyclines when admin concomitantly. Phosphorus-containing preparations reduce zinc absorption. Zn sulfate reduces absorption of copper and flouroquinolones e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin. Reduced zinc absorption with calcium co-admin. Reduced bisphosphonates absorption with concurrent zinc admin.

Food Interactions

Absorption of Zn sulfate is reduced by milk, phytates (present in cereals, rice, corn, legumes) and some minerals (e.g. iron, calcium).

Mechanism of Actions

As an ophthalmic preparation, zinc sulfate precipitates protein and this is responsible for the astringent and weak antiseptic activity of Zn sulfate. It also produces mild vasodilation. Zinc sulfate can also be used orally or systemically as a zinc supplement. 220 mg of zinc sulfate (heptahydrate) contains 50 mg of elemental zinc.
Absorption: Following oral administration, 20-30% of dietary Zn is absorbed.
Distribution: Widely distributed but concentrated within the muscle, bone, skin and prostatic fluids.
Excretion: Primarily via faeces at approx 90%; small amounts via urine at approx 2% and via perspiration.

Administration

Ophthalmic: Store below 40°C.

ATC Classification
A12CB01
GenericPedia Classification
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  • Available As
  • Zinc Sulphate –
  • Zinc Sulphate 0.0004% w/v
  • Zinc Sulphate 0.004%
  • Zinc Sulphate 0.004% w/v
  • Zinc Sulphate 0.01% w/v
  • Zinc Sulphate 0.012% w/v
  • Zinc Sulphate 0.025%
  • Zinc Sulphate 0.025% w/w
  • Zinc Sulphate 0.05 mg
  • Zinc Sulphate 0.1 mg
  • Zinc Sulphate 0.1 w/v
  • Zinc Sulphate 0.1%
  • Zinc Sulphate 0.1% w/v
  • Zinc Sulphate 0.108 gm
  • Zinc Sulphate 0.12%
  • Zinc Sulphate 0.12% w/v
  • Zinc Sulphate 0.15 mg
  • Zinc Sulphate 0.2 mg
  • Zinc Sulphate 0.2%
  • Zinc Sulphate 0.5 mg
  • Zinc Sulphate 0.5%
  • Zinc Sulphate 0.5% w/w
  • Zinc Sulphate 0.6 mg
  • Zinc Sulphate 1 mg
  • Zinc Sulphate 1.05 mg
  • Zinc Sulphate 1.25 mg
  • Zinc Sulphate 1.33 mg
  • Zinc Sulphate 1.5 mg
  • Zinc Sulphate 1.8 mg
  • Zinc Sulphate 10 mcg
  • Zinc Sulphate 10 mg
  • Zinc Sulphate 10.3 mg
  • Zinc Sulphate 10.98 mg
  • Zinc Sulphate 100 mg
  • Zinc Sulphate 11 mg
  • Zinc Sulphate 12 mg
  • Zinc Sulphate 12.5 mg
  • Zinc Sulphate 120 mg
  • Zinc Sulphate 13.19 mg
  • Zinc Sulphate 13.3 mg
  • Zinc Sulphate 13.5 mg
  • Zinc Sulphate 13.73 mg
  • Zinc Sulphate 137.5 mg
  • Zinc Sulphate 14.8 mg
  • Zinc Sulphate 140 mg
  • Zinc Sulphate 15 mg
  • Zinc Sulphate 15.1 mg
  • Zinc Sulphate 16.5 mg
  • Zinc Sulphate 16.8 mg
  • Zinc Sulphate 17.6 mg
  • Zinc Sulphate 17.60 mg
  • Zinc Sulphate 18 mg
  • Zinc Sulphate 2 mg
  • Zinc Sulphate 2%
  • Zinc Sulphate 2% w/v
  • Zinc Sulphate 2% w/w
  • Zinc Sulphate 2.2 mg
  • Zinc Sulphate 2.20 mg
  • Zinc Sulphate 2.5 mg
  • Zinc Sulphate 2.5%
  • Zinc Sulphate 2.5% w/w
  • Zinc Sulphate 2.50%
  • Zinc Sulphate 2.66 mg
  • Zinc Sulphate 2.67 mg
  • Zinc Sulphate 2.7 mcg
  • Zinc Sulphate 2.7 mg
  • Zinc Sulphate 2.70 mg
  • Zinc Sulphate 2.75 mg
  • Zinc Sulphate 20 mg
  • Zinc Sulphate 20.59 mg
  • Zinc Sulphate 20.6 mg
  • Zinc Sulphate 20.61 mg
  • Zinc Sulphate 200 mg
  • Zinc Sulphate 21 mg
  • Zinc Sulphate 21.8 mg
  • Zinc Sulphate 21.98 mg
  • Zinc Sulphate 22 mg
  • Zinc Sulphate 22.2 mg
  • Zinc Sulphate 22.45 mg
  • Zinc Sulphate 22.5 mcg
  • Zinc Sulphate 22.5 mg
  • Zinc Sulphate 22.50 mg
  • Zinc Sulphate 22.51 mg
  • Zinc Sulphate 22.6 mg
  • Zinc Sulphate 220 mg
  • Zinc Sulphate 23 mcg
  • Zinc Sulphate 23 mg
  • Zinc Sulphate 24.75 mg
  • Zinc Sulphate 25 mg
  • Zinc Sulphate 27 mg
  • Zinc Sulphate 27.4 mg
  • Zinc Sulphate 27.45 mcg
  • Zinc Sulphate 27.45 mg
  • Zinc Sulphate 27.5 mg
  • Zinc Sulphate 27.50 mg
  • Zinc Sulphate 27.54 mg
  • Zinc Sulphate 28.7 mg
  • Zinc Sulphate 3 mg
  • Zinc Sulphate 3.3 mg
  • Zinc Sulphate 30 mcg
  • Zinc Sulphate 30 mg
  • Zinc Sulphate 30.9 mg
  • Zinc Sulphate 31 mg
  • Zinc Sulphate 31.6 mg
  • Zinc Sulphate 32 mg
  • Zinc Sulphate 32.38 mg
  • Zinc Sulphate 32.5 gm
  • Zinc Sulphate 32.5 mg
  • Zinc Sulphate 32.50 mg
  • Zinc Sulphate 32.5gm
  • Zinc Sulphate 32.5mg
  • Zinc Sulphate 33 mg
  • Zinc Sulphate 333 mg
  • Zinc Sulphate 35 mcg
  • Zinc Sulphate 35 mg
  • Zinc Sulphate 39 mg
  • Zinc Sulphate 4 mg
  • Zinc Sulphate 4% w/v
  • Zinc Sulphate 4.4 mg
  • Zinc Sulphate 40 mg
  • Zinc Sulphate 41 mg
  • Zinc Sulphate 41.18 mg
  • Zinc Sulphate 41.2 mg
  • Zinc Sulphate 41.4 mg
  • Zinc Sulphate 42.5 mg
  • Zinc Sulphate 43 mg
  • Zinc Sulphate 44 mg
  • Zinc Sulphate 44.4 mg
  • Zinc Sulphate 45 mg
  • Zinc Sulphate 5 mg
  • Zinc Sulphate 50 mg
  • Zinc Sulphate 53 mg
  • Zinc Sulphate 54.93 mg
  • Zinc Sulphate 55 mg
  • Zinc Sulphate 57 mg
  • Zinc Sulphate 6 mg
  • Zinc Sulphate 6.1 mg
  • Zinc Sulphate 6.18 mg
  • Zinc Sulphate 6.6 mg
  • Zinc Sulphate 6.7 mg
  • Zinc Sulphate 60 mg
  • Zinc Sulphate 61 mg
  • Zinc Sulphate 61.08 mg
  • Zinc Sulphate 61.5 mg
  • Zinc Sulphate 61.6 mg
  • Zinc Sulphate 61.8 mcg
  • Zinc Sulphate 61.8 mg
  • Zinc Sulphate 61.80 mg
  • Zinc Sulphate 62 mg
  • Zinc Sulphate 63 mg
  • Zinc Sulphate 65 mg
  • Zinc Sulphate 66 mg
  • Zinc Sulphate 66.5 mg
  • Zinc Sulphate 66.6 mg
  • Zinc Sulphate 66.7 mg
  • Zinc Sulphate 66.8 mg
  • Zinc Sulphate 68 mg
  • Zinc Sulphate 68.67 mg
  • Zinc Sulphate 68.8 mg
  • Zinc Sulphate 7 mg
  • Zinc Sulphate 7.0 mg
  • Zinc Sulphate 7.2 mg
  • Zinc Sulphate 7.45 mg
  • Zinc Sulphate 7.5 mg
  • Zinc Sulphate 7.50 mg
  • Zinc Sulphate 7.5mg
  • Zinc Sulphate 70 mg
  • Zinc Sulphate 705 mg
  • Zinc Sulphate 75 mcg
  • Zinc Sulphate 75 mg
  • Zinc Sulphate 8 mg
  • Zinc Sulphate 8.0 mg
  • Zinc Sulphate 80 mg
  • Zinc Sulphate 81.3 mg
  • Zinc Sulphate 88 mg
  • Zinc Sulphate 88.8 mg
  • Zinc Sulphate 9.23 mg
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