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Vit A indications, dose, side effects & concise monograph

Vit A

Indications
Oral
Vitamin A deficiency
Adult: For severe deficiency with corneal changes: 500,000 units daily for 3 days, followed by 50,000 units daily for 2 wk and then 10,000-20,000 units daily for 2 mth as follow-up therapy. For cases with corneal changes: 10,000-25,000 units daily until clinical improvement occurs (usually 1-2 wk).
Child: In children with xerophthalmia: 5000 units/kg daily for 5 days or until recovery occurs.
Intramuscular
Patients with biliary cirrhosis or chronic cholestatic liver disease
Adult: 100,000 units every 2-4 mth.
Topical/Cutaneous
Psoriasis
Adult: Apply as cream or ointment on affected areas.
Topical/Cutaneous
Acne
Adult: Apply as cream or ointment on affected areas.
Contraindications
Hypervitaminosis A; pregnancy (dose exceeding RDA).
Warnings / Precautions
Cholestatic jaundice; fat-malabsorption conditions. Monitor patients closely for toxicity. Liver impairment and children.
Adverse Reactions
Hypervitaminosis A characterised by fatigue, irritability, anorexia, weight loss, vomiting and other GI disturbances, low-grade fever, hepatosplenomegaly, skin changes, alopoecia, dry hair, cracking and bleeding lips, SC swelling, nocturia, pains in bones and joints.
Drug Interactions
Decreased absorption with neomycin. Increased risk of hypervitaminosis A with synthetic retinoids eg, acitretin, isotretinoin and tretinoin. Increased risk of toxicity when used with alcohol.
See Below for More retinol Drug Interactions
Mechanism of Actions
Retinol (vitamin A) is an essential cofactor in many biological processes for growth, development and maintenance of epithelial tissues and visual adaptation to darkness
Absorption: Well-absorbed from GI tract (except in the presence of fat malabsorption, low-protein intake, impaired hepatic or pancreatic function) after oral administration.
Distribution: Concentrated in the liver. Enters breastmilk.
Metabolism: Hydrolysed to retinol by pancreatic enzymes.
Excretion: Urine and faeces.
ATC Classification
D10AD02 - retinol ; Belongs to the class of topical retinoid preparations used in the treatment of acne.
R01AX02 - retinol ; Belongs to the class of other nasal preparations for topical use.
S01XA02 - retinol ; Belongs to the class of other ophthalmologicals.
Available As
  • Vit A 0.1%
  • Vit A 0.94 mg
  • Vit A 1 mg
  • Vit A 1.47 mg
  • Vit A 10 mg
  • Vit A 10,000 iu
  • Vit A 10.33 mg
  • Vit A 100 iu
  • Vit A 1000 iu
  • Vit A 10000 iu
  • Vit A 100000 iu
  • Vit A 1080 iu
  • Vit A 1100 iu
  • Vit A 1170 iu
  • Vit A 1200 iu
  • Vit A 12000 iu
  • Vit A 1250 iu
  • Vit A 1250 mcg
  • Vit A 1295 mcg
  • Vit A 1300 iu
  • Vit A 1305 iu
  • Vit A 15 mcg
  • Vit A 150 mg
  • Vit A 1500 iu
  • Vit A 1500 mcg
  • Vit A 150000 iu
  • Vit A 1520 iu
  • Vit A 1560 iu
  • Vit A 1575 iu
  • Vit A 1600 iu
  • Vit A 1650 iu
  • Vit A 166 iu
  • Vit A 1666 iu
  • Vit A 1800 iu
  • Vit A 1900 iu
  • Vit A 2 mg
  • Vit A 2%
  • Vit A 20 mg
  • Vit A 200 iu
  • Vit A 2000 iu
  • Vit A 202.5 iu
  • Vit A 203 iu
  • Vit A 2083 iu
  • Vit A 211.5 iu
  • Vit A 2330 iu
  • Vit A 2333.33 iu
  • Vit A 240.75 iu
  • Vit A 25 iu
  • Vit A 25 mg
  • Vit A 250 iu
  • Vit A 2500 i.u
  • Vit A 2500 iu
  • Retinol 2500 iu
  • Vit A 2500 mcg
  • Vit A 25000 iu
  • Vit A 260 mcg
  • Vit A 2700 iu
  • Vit A 2704.8 iu
  • Vit A 2714.8 iu
  • Vit A 2714.81 iu
  • Vit A 272.48 iu
  • Vit A 273.4 iu
  • Vit A 2750 iu
  • Vit A 293 mcg
  • Vit A 300 iu
  • Vit A 3000 iu
  • Vit A 3000 mg
  • Vit A 320 mcg
  • Vit A 3250 iu
  • Vit A 3300 iu
  • Vit A 3330 iu
  • Vit A 345 iu
  • Vit A 345 mcg
  • Vit A 350 mcg
  • Vit A 3500 iu
  • Vit A 357 mcg
  • Vit A 375 mcg
  • Vit A 390 mcg
  • Vit A 400 iu
  • Vit A 4000 iu
  • Vit A 4200 iu
  • Vit A 450 mcg
  • Vit A 4800 iu
  • Vit A 5 mg
  • Vit A 50,000 iu
  • Vit A 500 i.u
  • Vit A 500 iu
  • Vit A 500 mcg
  • Retinol 500 mcg
  • Vit A 5000 i.u.
  • Vit A 5000 iu
  • Vit A 5000 mg
  • Vit A 50000 iu
  • Vit A 524.02 mcg
  • Vit A 5330 iu
  • Vit A 5333 iu
  • Vit A 5400 iu
  • Vit A 550 iu
  • Vit A 5500 iu
  • Vit A 551 iu
  • Vit A 551 mcg
  • Vit A 555 iu
  • Vit A 570 iu
  • Vit A 577 mcg
  • Vit A 600 mcg
  • Vit A 6000 iu
  • Vit A 6200 iu
  • Vit A 625 iu
  • Vit A 628 iu
  • Vit A 670 mcg
  • Vit A 707.4 mcg
  • Vit A 750 iu
  • Vit A 750 mcg
  • Vit A 7500 iu
  • Vit A 75000 iu
  • Vit A 790.58 iu
  • Vit A 800 iu
  • Vit A 8000 iu
  • Vit A 826 mcg
  • Vit A 8300 iu
  • Vit A 8330 iu
  • Vit A 837 mcg
  • Vit A 848 mcg
  • Vit A 955 iu
  • Vit A 960 mcg
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