Valdecoxib

Indications
Oral
Osteoarthritis
Adult: 10 mg once daily.
CrCl (ml/min)Dosage Recommendation
<30Initiate with caution.
Hepatic impairment: Child-Pugh scale 7-9: Initiate with caution. Child-Pugh scale >10: Avoid.
Oral
Rheumatoid arthritis
Adult: 10 mg once daily.
CrCl (ml/min)Dosage Recommendation
<30Initiate with caution.
Hepatic impairment: Child-Pugh scale 7-9: Initiate with caution. Child-Pugh scale >10: Avoid.
Oral
Dysmenorrhoea
Adult: 20 mg bid.
Hepatic impairment: Child-Pugh scale 7-9: Initiate with caution. Child-Pugh scale >10: Avoid.
Contraindications
Hypersensitivity to sulfonamides, NSAIDs and other COX 2 inhibitors; asthma, urticaria; severe hepatic impairment; pregnancy (third trimester); lactation. Active GI bleed or ulceration, severe CHF, inflammatory bowel disease.
Warnings / Precautions
Mild to moderate hepatic impairment; history of ulcer disease or GI bleeding; dehydration, hypertension, history of heart failure, left ventricular dysfunction, pre-existing oedema. Monitor Hb or haematocrit values for signs and symptoms of anaemia.
Adverse Reactions
Hypertension, back pain, myalgia, peripheral oedema, influenza-like symptoms, dizziness, headache, abdominal fullness, abdominal pain, diarrhoea, dyspepsia, flatulence, nausea, myalgia, sinusitis.
Potentially Fatal: Toxic epidermal necrolysis, exfoliative dermatitis.
Drug Interactions
Concomitant admin of aspirin may result in an increased risk of GI ulceration and complications. It decreases the antihypertensive effect of antihypertensives e.g. ACE inhibitors. It increases plasma conc of dextromethorphan. It significantly decreases lithium serum clearance and renal clearance.
See Below for More valdecoxib Drug Interactions
Mechanism of Actions
Valdecoxib acts by selectively inhibiting prostaglandin synthesis primarily by blocking cyclooxygenase (COX-2) enzyme. It was withdrawn worldwide in April 2005, following risk of serious skin reactions and cardiovascular side effects.
Onset: 60 min.
Absorption: Peak plasma concentrations after 2.25-3 hrs (oral).
Distribution: Protein-binding: 98%
Metabolism: Extensively hepatic.
Excretion: Urine (as metabolites); 8-11 hrs (elimination half-life).
Administration
May be taken with or without food.
Storage Conditions
Oral: Store below 30°C.
ATC Classification
M01AH03 - valdecoxib ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, coxibs.
Storage
Oral: Store below 30°C.
Available As
  • Valdecoxib 10 mg
  • Valdecoxib 100 mg
  • Valdecoxib 20 mg
  • Valdecoxib 40 mg
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