Tetanus Toxoid

Indications
 Parenteral
Active immunisation against tetanus
Adult: Primary immunisation (using tetanus toxoid adsorbed via deep IM Inj): 3 doses of 0.5 ml each; 2nd dose is given 4-8 wk after the 1st dose and the 3rd dose is given 6-12 mth after the 2nd dose. Booster dose (using tetanus toxoid via IM/SC or tetanus toxoid adsorbed via deep IM): 0.5 ml every 10 yr. Pregnant women who have not completed primary vaccination against tetanus: if insufficient time, 2 doses at least 4 wk apart (wait until second trimester to reduce risk to foetus), and 2nd dose at least 2 wk before delivery.
Child: ≥7 yr: Primary immunisation (using tetanus toxoid adsorbed via deep IM Inj): 3 doses of 0.5 ml each; 2nd dose is given 4-8 wk after the 1st dose and the 3rd dose is given 6-12 mth after the 2nd dose. Booster dose (using tetanus toxoid via IM/SC or tetanus toxoid adsorbed via deep IM): 0.5 ml every 10 yr.
Parenteral
Postexposure prophylaxis of tetanus
Adult: Emergency booster dose of 0.5 ml tetanus toxoid (IM/SC) or tetanus toxoid adsorbed (Deep IM Inj) to be given: if previously received <3 doses of a tetanus toxoid-containing preparation. Emergency dose is also needed if the wound is clean and minor and >10 yr have lapsed since primary immunisation or last booster dose of tetanus toxoid-containing preparation. For all other wounds, emergency dose is needed if >5 yr have lapsed since primary immunisation or the last booster dose of tetanus toxoid-containing preparation.
Warnings / Precautions
 Do not administer IV. Use subcutaneous route in bleeding disorders. Withhold vaccination in moderate or severe febrile illness. Pregnancy, lactation, history of Guillian-Barre syndrome.
Adverse Reactions
 Mild inj site reactions eg transient swelling, rash, fever, malaise, tiredness, nausea, vomiting, arthralgias, pruritus, dizziness.
Potentially Fatal: Anaphylactic reactions.
Drug Interactions
 Decreased immunologic response with concurrent immunosuppressants. Neutralisation of tetanus immune globulin and tetanus toxoid adsorbed if not given at different sites using different syringes.
See Below for More vaccine, tetanus toxoid, tetanus toxoid adsorbed Drug Interactions
Mechanism of Actions
 Tetanus toxoid and tetanus toxoid adsorbed induces active immunity to the tetanus antigen by stimulating the immune system to produce specific antitoxin. They are not indicated for the treatment of active tetanus infection.
Storage Conditions
 Parenteral: Store at 2-8°C. Do not freeze.
ATC Classification
 J07AM01 - tetanus toxoid ; Belongs to the class of tetanus bacterial vaccines.
Storage
 Parenteral: Store at 2-8°C. Do not freeze.
Available As
  • Tetanus Toxoid
  • Tetanus Toxoid –
  • Tetanus Toxoid 0.5 ml
  • Tetanus Toxoid 10 LF
  • Tetanus Toxoid 12 LF
  • Tetanus Toxoid 20 mcg
  • Tetanus Toxoid 5 LF
  • Tetanus Toxoid 60 iu
  • Tetanus Toxoid 7.5 LF

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