Terfenadine

Indications
 Oral
Allergic conditions
Adult: >12 yr and >50 kg: 60-120 mg in the morning or 60 mg bid. Max: 120 mg daily.
CrCl (ml/min)Dosage Recommendation
<40Half the usual daily dose
Contraindications
 Porphyria.
Warnings / Precautions
 Child and elderly. Avoid in patients with cardiac or significant hepatic disease, electrolyte imbalance, or known or suspected prolongation of the QT interval. Lactation, pregnancy.
Adverse Reactions
 Anxiety, palpitations, insomnia, mild GI distubances, erythema multiforme and galactorrhoea.
Potentially Fatal: Ventricular arrhythmias including torsades de pointes. Palpitations, dizziness, syncope or convulsions may indicate arrhythmias. Hepatitis.
Drug Interactions
 Potentially Fatal: Increased risk of ventricular arrhythmia with triazole and imidazole antifungals, macrolide antibacterials, streptogramin antibacterials, SSRI, HIV-protease inhibitors and non-nucleoside reverse transcriptase inhibitors, arrhythmogenic drugs, diuretics, astemizole and zileutron.
See Below for More terfenadine Drug Interactions
Food Interactions
 Grapefruit juice may inhibit the metabolism of terfenadine.
Mechanism of Actions
 Terfenadine, a piperidine derivative, is a non-sedating H1 receptor antagonist antihistamine.
Absorption: Rapidly absorbed from GI tract. Peak plasma concentrations: within 2 hr.
Distribution: Protein binding: 97% (terfenadine). Does not appear to cross the blood-brain barrier to significant extent. Limited amounts of fexofenadine, but not terfenadine detected in breast milk. Elimination half-life: 16-23 hr (terfenadine).
Metabolism: Prodrug and undergoes extensive first-pass metabolism in the liver to active (carboxylic acid derivative fexofenadine) and inactive metabolites.
Excretion: Excreted in the urine and faeces (traces of unchanged drug and metabolites)
ATC Classification
 R06AX12 - terfenadine ; Belongs to the class of other antihistamines for systemic use.
Available As
  • Terfenadine 120 mg
  • Terfenadine 30 mg
  • Terfenadine 60 mg

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