Tazarotene

Indications
Topical/Cutaneous
Stable plaque psoriasis
Adult: >18 yr: Apply a thin layer of 0.05% or 0.1% cream or gel to cleansed dry affected area, once daily in the evening. If needed, moisturiser should be applied at least 1 hr prior to application of tazarotene.
Topical/Cutaneous
Acne
Adult: >12 yr: Apply a thin layer of 0.1% cream or gel to cleansed dry affected area, once daily in the evening.
Topical/Cutaneous
Photoaging
Adult: >17 yr: Apply a thin layer of 0.1% cream or gel to cover entire face (including eyelids) once daily before retiring.
Contraindications
Pregnancy, lactation. Eczema. Sunburnt conditions. Hypersensitivity.
Warnings / Precautions
Avoid contact with eyes, mouth, mucous membranes. Abraded skin. Avoid exposure to sun or UV light. Do not use >10% of BSA. Do not use cream with occlusive dressing. Wash hands after application. Do not use cream/gel in amounts more than instructed. Women of child bearing potential should take birth control measures. Negative pregnancy test to be obtained within 2 wk prior to initiation and start therapy during normal menstrual period.
Adverse Reactions
Pruritus, burning/stinging, erythema, skin peeling, irritation, worsening of psoriasis, rash, dry skin, bleeding, localised oedema, hypertriglyceridaemia, desquamation, contact dermatitis, discolouration of skin, photosensitivity.
Overdose Reactions
Excessive topical use cause marked redness, peeling or discomfort. Accidental oral ingestion produces similar adverse effects as those associated with excessive oral intake of Vitamin A or other retinoids. Monitor and take supportive measures as necessary.
Drug Interactions
Increased drying effect effect with concomitant use of dermatologic medications and cosmetics that have irritant or strong drying effect. Increased risk of photosensitivity with drugs known to be photosensitisers.
See Below for More tazarotene Drug Interactions
Mechanism of Actions
Tazarotene is a synthetic acetylenic retinoid, that is applied topically. It is de-esterified in the skin to its active form, tazarotenic acid, which affects cell proliferation and differentiation by modulating gene expression in acne and psoriasis.
Distribution: Tazarotenic acid: >99% bound to plasma proteins, half-life:18 hr.
Metabolism: Undergoes esterase hydrolysis to form its active metabolite, tazarotenic acid.
Excretion: Eliminated via urine and faeces.
ATC Classification
D05AX05 - tazarotene ; Belongs to the class of other antipsoriatics for topical use.
Available As
  • Tazarotene 0.05%
  • Tazarotene 0.1%
  • Tazarotene 0.1% w/w
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