Indications |
Oral Chronic gastritis Adult: 1 g 4 times daily or 2 g bid for 4-8 wk, may extend up to 12 wk if necessary. Maintenance dose of 1 g bid may be given to prevent the recurrence of duodenal ulcers. Max: 8 g daily. Child: 1 mth-2 yr: 250 mg 4-6 times daily; 2-12 yr: 500 mg 4-6 times daily and 12-18 yr: 1 g 4-6 times daily. Oral Peptic ulcer Adult: 1 g 4 times daily or 2 g bid for 4-8 wk, may extend up to 12 wk if necessary. Maintenance dose of 1 g bid may be given to prevent the recurrence of duodenal ulcers. Max: 8 g daily. Child: 1 mth-2 yr: 250 mg 4-6 times daily; 2-12 yr: 500 mg 4-6 times daily and 12-18 yr: 1 g 4-6 times daily. Oral Prophylaxis of gastrointestinal haemorrhage from stress ulceration Adult: 1 g 6 times daily. Not to exceed 8 g daily. Child: 1 mth-2 yr: 250 mg 4-6 times daily; 2-12 yr: 500 mg 4-6 times daily and 12-18 yr: 1 g 4-6 times daily. |
Warnings / Precautions |
Systemic aluminum toxicity may occur in patients with chronic renal failure. Neonates, children; pregnancy and lactation. |
Adverse Reactions |
Constipation, diarrhoea, nausea, dizziness, dry mouth. GI disturbances, rash, pruritus, headache, vertigo, back pain, drowsiness. |
Overdose Reactions |
Sucralfate is poorly absorbed from the GI tract thus the risk from overdosage is minimal. |
Drug Interactions |
Avoid antacids within 30 min of sucralfate admin. May reduce absorption of tetracyclines, ranitidine, ketoconazole, theophylline, phenytoin, cimetidine and digoxin (ensure a dosing interval of at least 2 hr between admin of sucralfate and other non-antacid medications). See Below for More sucralfate Drug Interactions |
Mechanism of Actions |
Sucralfate protects GI lining against peptic acid, pepsin and bile salts by binding with positively-charged proteins in exudates forming a viscous paste-like adhesive substance thus forming a protective coating. Onset: 1-2 hr. Duration: 6 hr. Absorption: <5% after oral admin. Distribution: Acts locally at ulcer sites; unbound in GI tract to aluminum and sucrose sulfate. Excretion: Mainly in the urine. |
Administration |
Should be taken on an empty stomach. (Take on an empty stomach 1 hr before or 2 hr after meals.) |
Storage Conditions |
Oral: Store at 20-25°C. |
ATC Classification |
A02BX02 - sucralfate ; Belongs to the class of other drugs used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD). |
Storage |
Oral: Store at 20-25°C. |
Available As |
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Sucralfate
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Sucralfate Containing Brands
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