Secnidazole

Indications
 Oral
Severe invasive amoebiasis
Adult: 1.5 g daily as single or in divided doses for 5 days.
Child: 30 mg/kg daily for 5 days.
Oral
Trichomoniasis
Adult: 2 g as a single dose.
Child: 30 mg/kg as a single dose.
Oral
Amoebiasis
Adult: 2 g as a single dose.
Child: 30 mg/kg as a single dose.
Oral
Giardiasis
Adult: 2 g as a single dose.
Child: 30 mg/kg as a single dose.
Contraindications
 Hypersensitivity; pregnancy (1st trimester) and lactation.
Warnings / Precautions
 Avoid alcohol and disulfiram. Avoid in patients with history of blood disorders.
Adverse Reactions
 Nausea, gastralgia, change of taste, metallic taste, stomatitis, urticaria, rashes, leucopenia. Rarely vertigo, moderate neurological, digestive disturbances.
Drug Interactions
 Concurrent disulfiram admin may cause psychotic reactions. Disulfiram-like reactions with alcohol. Cimetidine may prolong half-life.
Potentially Fatal: May potentiate anticoagulant effect of warfarin and increase risk of haemorrhage.
See Below for More secnidazole Drug Interactions
Mechanism of Actions
 Secnidazole is active against E histolytica, G lamblia, T vaginalis, Clostridium spp, B fragilis, Gardnerella spp. The drug enters the microorganisms by diffusion and is reduced intracellularly by low oxidation-reduction potential ferredoxin which then result in DNA damage.
ATC Classification
 P01AB07 - secnidazole ; Belongs to the class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases.
Available As
  • Secnidazole 1 gm
  • Secnidazole 1 gm (2 tab)
  • Secnidazole 1 mg
  • Secnidazole 1000 mg
  • Secnidazole 1000 mg (2 tab)
  • Secnidazole 2 gm
  • Secnidazole 2000 mg
  • Secnidazole 500 mg

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