Pyrazinamide

Indications
Oral
Tuberculosis
Adult: As part of a mulitdrug regimen, 20-25 mg/kg (max: 2 g) daily or 1.5-3 g 3 times wkly.
Child: As part of a mulitdrug regimen, 35 mg/kg daily or 50 mg/kg 3 times wkly or 75 mg/kg twice wkly. Max dose: 3 g daily.
Renal impairment: May need dose reduction.

Special Populations: Reduce dose in patients with renal impairment.
Contraindications
Hypersensitivity; existing liver disease; acute gout or hyperuricaemia. Porphyria. Pregnancy and lactation.
Warnings / Precautions
Diabetes, renal failure, history of gout, children. Monitor liver function and serum uric acid regularly.
Adverse Reactions
Hepatotoxicity (hepatomegaly, splenomegaly and jaundice may develop and in rare case fulminating acute yellow atrophy and death). Anorexia, nausea, vomiting, arthralgia, malaise, fever, hyperuricaemia, abnormal LFT, skin rashes.
Potentially Fatal: Severe liver damage, fulminant hepatitis.
Drug Interactions
Excretion may be blocked by probenecid.
See Below for More pyrazinamide Drug Interactions
Mechanism of Actions
Pyrazinamide has bactericidal action against M. tuberculosis in acid environment present in macrophages and inflammed tissue. Together with rifampicin provides greatest sterilising action with reduction in relapse rate. Reduces tubular secretion of uric acid.
Absorption: Readily absorbed from the GI tract (oral); peak plasma concentrations after 2 hr.
Distribution: Body fluids and tissues (wide), CSF, enters breast milk.
Metabolism: Hepatic; hydrolysed to pyrazinoic acid (active) then hydroxylated to 5-hydroxypyrazinoic acid (major excretory product).
Excretion: Via urine by glomerular filtration (70% as metabolites, 4-14% as unchanged); 9-10 hr (elimination half-life), removed by dialysis.
Administration
Should be taken with food.
Storage Conditions
Oral: Store at 15-30°C.
ATC Classification
J04AK01 - pyrazinamide ; Belongs to the class of other drugs used in the systemic treatment of tuberculosis.
Storage
Oral: Store at 15-30°C.
Available As
  • Pyrazinamide 1000 mg
  • Pyrazinamide 1000 mg (2 tab)
  • Pyrazinamide 1200 mg
  • Pyrazinamide 150 mg
  • Pyrazinamide 1500 mg
  • Pyrazinamide 225 mg
  • Pyrazinamide 250 mg
  • Pyrazinamide 300 mg
  • Pyrazinamide 350 mg
  • Pyrazinamide 375 mg
  • Pyrazinamide 400 mg
  • Pyrazinamide 500 mg
  • Pyrazinamide 750 mg
  • Pyrazinamide 750 mg (2 tab)
  • Pyrazinamide 800 mg
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    Pyrazinamide Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Akurit Z Kid (150+30+60) Lupin Laboratories Ltd. 1 Tablet
    ₹ 1.09
    6 Tablet
    ₹ 6.54
  • More Information Isoniazid 30 mg
  • More Information Rifampicin 60 mg
  • More Information Pyrazinamide 150 mg
  • See Brands having above combination
    Tablet Actuate Z Kid (150+30+60) Biocin Genetics & Pharma 1 Tablet
    ₹ 1.95
    100 Tablet
    ₹ 195.00
  • More Information Isoniazid 30 mg
  • More Information Rifampicin 60 mg
  • More Information Pyrazinamide 150 mg
  • See Brands having above combination
    Tablet Alzide (500 mg) Overseas Health Care Pvt. Ltd. 1 Tablet
    ₹ 1.30
    10 Tablet
    ₹ 13.00
  • More Information Pyrazinamide 500 mg
  • See Brands having above combination
    Tablet Binex Z (750+225+150) Biological Evans Ltd 1 Tablet
    ₹ 1.02
    10 Tablet
    ₹ 10.21
  • More Information Pyrazinamide 750 mg
  • More Information Isoniazid 150 mg
  • More Information Rifampicin 225 mg
  • See Brands having above combination
    Tablet Exact ZH kid (60+30+150) Marc Laboratories Pvt. Ltd. 1 Tablet
    ₹ 0.89
    10 Tablet
    ₹ 8.85
  • More Information Isoniazid 30 mg
  • More Information Rifampicin 60 mg
  • More Information Pyrazinamide 150 mg
  • See Brands having above combination
    Syrup Kemiron (100 ml) Anikem Laboratories 5 ml
    ₹ 1.25
    100 ml
    ₹ 25.00
  • More Information Pyrazinamide 750 mg
  • See Brands having above combination
    Tablet Macox ZH DT (300+100+50) Macleods Pharmaceuticals Pvt Ltd. 1 Tablet
    ₹ 1.97
    10 Tablet
    ₹ 19.72
  • More Information Rifampicin 100 mg
  • More Information Isoniazid 50 mg
  • More Information Pyrazinamide 300 mg
  • See Brands having above combination
    Tablet Montorip Kid (300+100+50) Shreya Healthcare P. Ltd. 1 Tablet
    ₹ 1.70
    10 Tablet
    ₹ 17.01
  • More Information Rifampicin 100 mg
  • More Information Isoniazid 50 mg
  • More Information Pyrazinamide 300 mg
  • See Brands having above combination
    Tablet Pyrazinamide (500 mg) (Unicure) Unicure (India) Pvt.Ltd. 1 Tablet
    ₹ 1.63
    10 Tablet
    ₹ 16.25
  • More Information Pyrazinamide 500 mg
  • See Brands having above combination
    Tablet Thamit IPR Finecure Pharmaceuticals Ltd 1 Tablet
    ₹ 0.90
    40 Tablet
    ₹ 36.00
  • More Information Ethambutol 400 mg
  • More Information Pyrazinamide 750 mg
  • More Information Isoniazid 150 mg
  • More Information Rifampicin 225 mg
  • See Brands having above combination
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    Pyrazinamide is used in following diseases

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    Drug - Drug Interactions of Pyrazinamide
    Interaction
    Moderate, Consider therapy modification Rifampin (rifampicin) vs Pyrazinamide
    Moderate, Consider therapy modification Pyrazinamide vs Rifampin
    Minor, Monitor Therapy Pyrazinamide vs CycloSPORINE (Systemic)
    Minor, Monitor Therapy Pyrazinamide vs CycloSPORINE
    Moderate, Consider therapy modification Rifampin, isoniazid, and pyrazinamide vs Calcium Channel Blockers
    Moderate, Consider therapy modification Rifampin, isoniazid, and pyrazinamide vs BusPIRone
    Minor, Monitor Therapy Rifampin, isoniazid, and pyrazinamide vs Brentuximab Vedotin
    Major, Avoid combination Rifampin, isoniazid, and pyrazinamide vs Boceprevir
    Minor, Monitor Therapy Rifampin, isoniazid, and pyrazinamide vs Beta-Blockers
    Moderate, Consider therapy modification Rifampin, isoniazid, and pyrazinamide vs Pyrazinamide
    Pages: 1 2 3 4 5 6 7 8 ... 13 14 15 Next