Indications |
Oral Progestogen component of menopausal hormonal replacement therapy Adult: 200 mg daily as a single daily dose at night for 12-14 days of each mth. Oral Amenorrhoea Adult: 400 mg daily for 10 days. Oral Dysfunctional uterine bleeding Adult: 400 mg daily for 10 days. Intramuscular Dysfunctional uterine bleeding Adult: 5-10 mg daily for 5-10 days until 2 days prior to expected onset of menstruation. Intramuscular Amenorrhoea Adult: 5-10 mg daily for 5-10 days until 2 days prior to expected onset of menstruation. Intramuscular Recurrent miscarriage with progesterone deficiency Adult: 25-100 mg twice wkly from the 15th day of pregnancy until 8-16 wk. May increase to daily inj, if necessary. Intrauterine Contraception Adult: Insert the device (containing 38 mg of progesterone) into the uterine cavity; efficacy can last up till 1 yr. Vaginal Dysfunctional uterine bleeding Adult: 45 mg every other day from the 15th-25th day of the cycle. May increase dose to 90 mg in non-responders. Vaginal Amenorrhoea Adult: 45 mg every other day from the 15th-25th day of the cycle. May increase dose to 90 mg in non-responders. Vaginal Premenstrual syndrome Adult: 200 mg daily, may increase to 400 mg bid. Treatment is usually started on days 12-14 of the cycle and continues until onset of menstruation. Same doses may also be given rectally. |
Contraindications |
Hypersensitivity; thrombophloebitis; cerebral apoplexy; severe hepatic impairment; undiagnosed vag bleeding, incomplete abortion, hormone-dependent carcinoma, as a diagnostic test for pregnancy; pregnancy. History or current high risk of arterial disease. |
Warnings / Precautions |
Discontinue medications if there is sudden partial or complete loss of vision, proptosis or diplopia; migraine and embolic disorders; epilepsy, migraine, asthma, cardiac or renal dysfunction. History of depression, glucose tolerance and diabetic patients. May impair ability to drive or operate machinery. Avoid sudden withdrawal of progesterone; lactation. |
Adverse Reactions |
GI disturbances, appetite/wt change, fluid retention, oedema, acne, skin rash, urticaria, depression, headache, fever, fatigue, breast changes, hirsutism, changes in libido, altered menstrual cycles or irregular menstrual bleeding (rare). |
Drug Interactions |
Enhanced clearance with enzyme-inducing drugs eg, carbamazepine, griseofulvin, phenobarbital, phenytoin and rifampicin. Ketoconazole may increase serum levels of progesterone. May inhibit ciclosporin metabolism. See Below for More progesterone Drug Interactions |
Lab Interactions |
May alter serum lipid profile and rarely, LFTs. |
Mechanism of Actions |
Progesterone is the main hormone secreted by corpus luteum. It induces secretory changes in the endometrium, promotes mammary gland development, relaxes uterus, blocks follicular maturation and ovulation, and maintains pregnancy. Absorption: Oral bioavailability is low. Distribution: Highly bound to plasma proteins. Distributes into breast milk. Metabolism: Hepatic; extensive 1st-pass effect. Excretion: Via the urine (as sulfate and glucuronide conjugates). |
Administration |
Should be taken on an empty stomach (i.e. At least one hour before food or two hours after food). |
ATC Classification |
G03DA04 - progesterone ; Belongs to the class of pregnen (4) derivative progestogens. |
Available As |
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Progesterone
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Progesterone Containing Brands
Progesterone is used in following diseases
Drug - Drug Interactions of Progesterone
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