Indications |
Oral Schistosomiasis Adult: 3 doses of 20 mg/kg every 4-6 hr or 40-60 mg/kg as a single dose. Child: >4 yr: Same as adult dose. Oral Intestinal fluke infections Adult: 25 mg/kg tid for 1-2 days or 40 mg/kg as a single daily dose. Child: >4 yr: Same as adult dose. Oral Lung fluke infections Adult: 25 mg/kg tid for 1-2 days or 40 mg/kg as a single daily dose. Child: >4 yr: Same as adult dose. Oral Clonorchiasis Adult: 25 mg/kg tid for 1-2 days or 40 mg/kg as a single daily dose. Child: >4 yr: Same as adult dose. Oral Opisthorchiasis Adult: 25 mg/kg tid for 1-2 days or 40 mg/kg as a single daily dose. Child: >4 yr: Same as adult dose. Oral Tapeworm infections Adult: 5-25 mg/kg as a single dose. Child: >4 yr: Same as adult dose. Oral Neurocysticercosis Adult: 50 mg/kg/day, given in 3 divided doses for 14 days. Alternatively, 3 doses of 25 mg/kg every 2 hr. |
Contraindications |
Hypersensitivity, ocular cysticercosis. |
Warnings / Precautions |
Driving or operating machinery during or for 24 hr after treatment. Severe hepatic disease. Do not breastfeed during or for 72 hr after treatment. |
Adverse Reactions |
Headache, drowsiness, dizziness, malaise, abdominal discomfort, nausea, vomiting, diarrhoea, urticaria, rashes, pruritus, fever, eosinophilia. |
Drug Interactions |
Reduced plasma concentrations when used with dexamethasone. Carbamazepine, phenytoin and chloroquine may reduce the bioavailability of praziquantel while cimetidine may increase the bioavailabilty of praziquantel. See Below for More praziquantel Drug Interactions |
Mechanism of Actions |
Praziquantel is an anthelmintic with a broad spectrum of activity against trematodes (flukes) and cestodes (tapeworms). It increases the cell permeability to Ca in schistosomes, causing strong contractions and paralysis of worm musculature leading to detachment of suckers from the blood vessel walls and to dislodgement. Absorption: 80% of dose is rapidly absorbed from the GIT (oral); peak plasma concentrations after 1-3 hr. Distribution: CSF, enters breast milk. Metabolism: Rapid and extensive hepatic first-pass metabolism by hydroxylation. Excretion: Via urine (as metabolites); elimination half-life: 1-1.5 hr (parent drug), 4 hr (metabolites). |
Administration |
Should be taken with food. (Swallow whole, do not chew/crush. ) |
ATC Classification |
P02BA01 - praziquantel ; Belongs to the class of quinoline derivatives and related substances used as antitrematodals. |
Available As |
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Praziquantel
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Praziquantel Containing Brands
Praziquantel is used in following diseases
Drug - Drug Interactions of Praziquantel
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