Nicotinamide

Indications
 Oral
Treatment and prophylaxis of nicotinic acid deficiency
Adult: Up to 500 mg daily in divided doses. May also be given via IM or by slow IV inj.
Topical/Cutaneous
Mild to moderate inflammatory acne
Adult: As a 4% gel: Apply bid, reduce to once daily or on alternate days if irritation occurs.
Warnings / Precautions
 Peptic ulcer; liver disease; gall bladder disease, DM; gout; bleeding problems. Pregnancy, lactation.
Adverse Reactions
 Elevated LFT values, liver damage e.g. jaundice, parenchymal liver cell injury; orthostatic hypotension; tachycardia, irregular heartbeat; nausea, vomiting, diarrhoea, abdominal pain; headache, dizziness, fever. Inj: skin rash, itching, wheezing. Topical: Dry skin, pruritus, erythema; burning sensation, irritation.
Drug Interactions
 May decrease clearance of carbamazepine and primidone.
See Below for More nicotinamide Drug Interactions
Mechanism of Actions
 Nicotinamide is a vitamin B3 derivative. It is incorporated into coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are involved in multiple cellular metabolic pathways.
Absorption: Readily absorbed from the GI tract.
Distribution: Widely distributed in the body tissues.
Metabolism: Hepatically metabolised.
Excretion: Small amounts excreted unchanged in the urine.
ATC Classification
 A11HA01 - nicotinamide ; Belongs to the class of other plain vitamin preparations. Used as dietary supplements.
Available As
  • Nicotinamide 1.25 mg
  • Nicotinamide 1.5 mg
  • Nicotinamide 10 mg
  • Nicotinamide 10.5 mg
  • Nicotinamide 100 mg
  • Nicotinamide 12 mg
  • Nicotinamide 15 mg
  • Nicotinamide 16 mg
  • Nicotinamide 16.70 mg
  • Nicotinamide 17 mg
  • Nicotinamide 19.8 mg
  • Nicotinamide 20 mg
  • Nicotinamide 200 mg
  • Nicotinamide 21 mg
  • Nicotinamide 22.5 mg
  • Nicotinamide 23 mg
  • Nicotinamide 25 mg
  • Nicotinamide 250 mcg
  • Nicotinamide 26 mg
  • Nicotinamide 3 mg
  • Nicotinamide 30 mg
  • Nicotinamide 33 mg
  • Nicotinamide 33.33 mg
  • Nicotinamide 4%
  • Nicotinamide 4% w/w
  • Nicotinamide 4.0% w/w
  • Nicotinamide 40 mg
  • Nicotinamide 45 mg
  • Nicotinamide 4900 mcg
  • Nicotinamide 5 mg
  • Nicotinamide 50 mg
  • Nicotinamide 500 mg
  • Nicotinamide 6.1 mg
  • Nicotinamide 7.5 mg
  • Nicotinamide 7.50 mg
  • Nicotinamide 75 mg
  • Nicotinamide 8 mg
  • Nicotinamide 8.30 mg
  • Nicotinamide 9 mg

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