Indications |
Oral Benign gastric and duodenal ulceration Adult: 800 mcg daily in 2-4 divided doses for at least 4 wk, up to 8 wk if needed. Elderly: Reduce dose if patients are unable to tolerate usual adult dose. Renal impairment: Reduce dose if patients are unable to tolerate usual adult dose. Oral NSAID-associated ulceration Adult: 800 mcg daily in 2-4 divided doses for at least 4 wk, up to 8 wk if needed. Elderly: Reduce dose if patients are unable to tolerate usual adult dose. Renal impairment: Reduce dose if patients are unable to tolerate usual adult dose. Oral Prophylaxis of NSAID-induced ulcers Adult: 200 mcg 2-4 times daily. Patient not tolerating high dose: Reduce dose to 100 mcg 2-4 times daily. Elderly: Reduce dose if patients are unable to tolerate usual adult dose. Renal impairment: Reduce dose if patients are unable to tolerate usual adult dose. Oral Cervical ripening before surgical termination of pregnancy in the 1st trimester Adult: 400 mcg as a single dose 3-4 hr before surgery. Oral Termination of pregnancy (49 days or less duration) Adult: 400 mcg as a single dose 36-48 hr after mifepristone. |
Contraindications |
Women of childbearing potential. Pregnancy and lactation. |
Warnings / Precautions |
Conditions where hypotension might precipitate severe complications e.g. cerebrovascular or CV disease. Inflammatory bowel disease. Patients prone to dehydration. Elderly. Renal impairment. |
Adverse Reactions |
Diarrhoea, abdominal pain, dyspepsia, constipation, flatulence, nausea and vomiting; abnormal vaginal bleeding, cramps, increased uterine contractility, headache. |
Overdose Reactions |
Symptoms: Sedation, tremor, convulsions, dyspnoea, abdominal pain, diarrhoea, hypotension, bradycardia. Management: Symptom-directed and supportive |
Drug Interactions |
May increase effects of oxytocin. Increased risk of misoprostol-induced diarrhoea with magnesium-containing antacids. See Below for More misoprostol Drug Interactions |
Mechanism of Actions |
Misoprostol, a synthetic prostaglandin E1 analogue, exerts its antisecretory activity by directly acting on specific prostaglandin receptors found on the surface of gastric parietal cells. It exerts its protective effects on the mucosa by replacing the prostaglandins consumed during prostaglandin-inhibiting therapies e.g. NSAIDs. Absorption: Rapidly absorbed from the GI tract (oral). Peak plasma concentration in 15-30 min. Metabolism: Rapidly metabolised to misoprostol acid (active form). Excretion: Mainly via urine. Elimination half-life: 20-40 min. |
Administration |
Should be taken with food. |
Storage Conditions |
Oral: Store at or below 25°C (77°F). |
ATC Classification |
G02AD06 - misoprostol ; Belongs to the class of prostaglandins. Used as an oxytocic. A02BB01 - misoprostol ; Belongs to the class of prostaglandins. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD). |
Storage |
Oral: Store at or below 25°C (77°F). |
Available As |
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Misoprostol
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Misoprostol Containing Brands
Misoprostol is used in following diseases
Drug - Drug Interactions of Misoprostol
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