Loratadine

Indications
 Oral
Allergic conditions
Adult: 10 mg once daily.
Child: 2-5 yr: 5 mg once daily. 6-12 yr: 10 mg once daily.
Renal impairment: Dosage may need to be reduced to alternate day admin.
Hepatic impairment: Dosage may need to be reduced to alternate day admin.

Special Populations: In patients with liver failure: Start with 10 mg on alternate days.
Contraindications
 Pregnancy, lactation, children <2 yr.
Warnings / Precautions
 Severe hepatic damage, epilepsy, renal insufficiency.
Adverse Reactions
 Fatigue, giddiness, dizziness, dry mouth, headache, nausea, somnolence.
Drug Interactions
 Plasma concentrations increased by ketoconazole, cimetidine, nefazodone, erythromycin and possibly other inhibitors of CYP3A4.
See Below for More loratadine Drug Interactions
Lab Interactions
 Reactions to skin testing procedures may be reduced.
Mechanism of Actions
 Loratadine is a non-sedating antihistamine. It works by selectively binding to peripheral histamine H1 -receptors on effector cells.
Absorption: Absorbed rapidly from the GI tract (oral); peak plasma concentrations after 1 hr. Absorption delayed by the presence of food.
Distribution: Enters breast milk, does not cross the blood-brain barrier. Protein-binding: 98%.
Metabolism: Extensively hepatic; converted to descarboethoxyloratadine (desloratadine).
Excretion: Via urine and faeces (as metabolites);elimination half-life 8.4 hr (loratadine) and 28 hr (desloratadine).
Administration
 May be taken with or without food.
ATC Classification
 R06AX13 - loratadine ; Belongs to the class of other antihistamines for systemic use.
Available As
  • Loratadine 1 mg
  • Loratadine 10 mg
  • Loratadine 2.5 mg
  • Loratadine 5 mg

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