Lisinopril

Indications
 Oral
Hypertension
Adult: Initially, 5-10 mg daily given at bedtime to avoid precipitous fall in BP. Patient with renovascular hypertension, volume depletion, severe hypertension: Initially, 2.5-5 mg once daily. Patient on diuretic: Initially, 5 mg once daily. Maintenance: 20 mg once daily, up to 80 mg daily may be used if needed.
Child: ≥6 yr: Initially, 0.07 mg/kg (up to 5 mg once daily). Adjust dose until desired BP goal is achieved.
Renal impairment: Adult: Dialysis: Initially 2.5 mg once daily. Max dose: 40 mg once daily. Child: Do not give if GFR <30 ml/min/1.73 m2.
CrCl (ml/min)Dosage Recommendation
31-80Initially 5-10 mg once daily.
10-30Initially 2.5-5 mg once daily.
<10Initially 2.5 mg once daily.

Oral
Heart failure
Adult: As adjunctive therapy: Initially, 2.5 mg daily. Maintenance: 5-40 mg daily as a single dose.
Oral
Post myocardial infarction
Adult: Initially, 5 mg once daily for 2 days started within 24 hr of the onset of symptoms. Increase to 10 mg once daily. Patients with low systolic BP: Initially, 2.5 mg once daily.
Oral
Diabetic nephropathy
Adult: For hypertensive type 2 diabetics with microalbuminuria: 10 mg once daily, may increase to 20 mg once daily to achieve a sitting diastolic BP <90 mmHg.
Contraindications
 History of angioedema related to previous treatment with ACE inhibitors, hereditary or idiopathic angioedema. Bilateral renal artery stenosis. Pregnancy (2nd or 3rd trimester), lactation.
Warnings / Precautions
 Hypovolaemia, hyperkalaemia, collagen vascular disease, valvular stenosis; before, during or immediately after anaesthesia, preexisting renal insufficiency, unilateral renal artery stenosis. Children <6 yr. Assess renal function. May impair ability to drive or operate machinery.
Adverse Reactions
 Dizziness, headache, fatigue; cough, upper respiratory tract infection; rash; diarrhoea, nausea, vomiting, abdominal pain; chest pain, weakness; orthostatic effects; hypotension; hyperkalaemia; impotence; decreased haemoglobin; increased serum creatinine.
Potentially Fatal: Severe hypotension, angioedema.
Overdose Reactions
 Symptom: Most likely hypotension. Treatment: Normal saline IV infusion may be used.
Drug Interactions
 Increased hypersensitivity reactions with allopurinol. Decreased serum levels with antacids. Reduced antihypertensive effect with aprotinin, NSAIDs, salicylates. May enhance the neutropenic effect of azathioprine. May enhance the nephrotoxic effect of ciclosporin. Increased risk of hyperkalaemia with eplerenone, potassium-sparing diuretics, trimethoprim. May enhance the adverse effects of ferric gluconate, gold sodium thiomalate. Increased risk of hypoglycaemia with insulin. Increased risk of neutropenia with mercaptopurine. Increased hypotensive effect and/or the nephrotoxic effect with thiazide diuretics.
Potentially Fatal: May increase serum level of lithium. Increased risk of adverse renal effects with NSAIDs, salicylates. Increased risk of acute hypotensive events or acute renal failure with loop diuretics.
See Below for More lisinopril Drug Interactions
Lab Interactions
 False-positive urine acetone determination results with sodium nitroprusside. Increases serum potassium and BUN/serum creatinine.
Food Interactions
 Avoid dong quai; ephedra, yohimbe, ginseng (may worsen hypertension).
Mechanism of Actions
 Lisinopril competitively inhibits angiotensin-converting enzyme (ACE) from converting angiotensin I to angiotensin II resulting in decreased levels of angiotensin II (a potent vasoconstrictor). This increases plasma renin activity and reduces aldosterone secretion. It also increases bradykinin levels.
Onset: 1-2 hr.
Duration: 24 hr (once daily dosing).
Absorption: Absorbed slowly and incompletely from the GI tract (oral); peak plasma concentrations after 7 hr.
Distribution: Protein-binding: Not significantly bound (25%).
Excretion: Via urine (as unchanged drug); 12 hr (elimination half-life).
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store at 15-30°C (59-86°F).
ATC Classification
 C09AA03 - lisinopril ; Belongs to the class of ACE inhibitors. Used in the treatment of cardiovascular disease.
Storage
 Oral: Store at 15-30°C (59-86°F).
Available As
  • Lisinopril 10 mg
  • Lisinopril 2.5 mg
  • Lisinopril 20 mg
  • Lisinopril 5 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Lisinopril


    Lisinopril Containing Brands

    We are Developing Our database, More results coming soon.

    Lisinopril is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Lisinopril

    We are Developing Our database, More results coming soon.