Isometheptene Mucate

Indications	Oral Acute migraine attacks *Adult:* As mucate: 130 mg at the onset of an attack, then 65 mg hrly thereafter as necessary. Max dose: 325 mg in 12 hr. *Max Dosage:* 325 mg in a 12-hr period.
Contraindications	Porphyria; severe hypertension; severe renal and hepatic impairment; organic heart disease.
Warnings / Precautions	CV diseases; hyperthyroidism; DM; pregnancy, lactation; angle-closure glaucoma.
Adverse Reactions	Dizziness, circulatory disturbances, rash, haematological disorders.
Drug Interactions	May antagonise hypotensive effects of adrenergic neurone blockers. Increased risk of hypertension with doxapram, oxytocin. Increased risk of ergotism with ergotamine and methysergide. Potentially Fatal: Increased risk of hypertensive crisis with MAOIs, moclobemide. Increased risk of toxicity (severe hypertension) with bromocriptine. See Below for More isometheptene Drug Interactions
Mechanism of Actions	Isometheptene is an indirect-acting sympathomimetic and acts as a vasoconstrictor.
Storage Conditions	Oral: Store at controlled room temperature 15-30°C (59-86°F).
ATC Classification	A03AX10 - isometheptene ; Belongs to the class of other drugs used for functional bowel disorders.
Storage	Oral: Store at controlled room temperature 15-30°C (59-86°F).
Available As	Isometheptene Mucate 65 mg

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